history in st. louis

Mississippi Valley Regional Blood Center came to the St. Louis area in 2005 and we have grown steadily ever since. Our reach now extends from Jefferson City, Missouri to Clay County, Illinois, and we now serve more than half the hospitals in St. Louis city and county.  

Operations are based out of Earth City, Missouri, in facility that houses our Reference Laboratory, Inventory Management and Distribution, and our Donor Services and Donor Relations teams. 

The blood center is currently growing it’s lab operations in St. Louis to expand support for local hospitals. For example, our Reference Laboratory has developed a registry of complex samples and identifies matching blood types for complex cases at local hospitals. We are also expanding our Component Production lab at the new facility in Earth City to increase production efficiency and make the most of donations made in the St. Louis region.

The Blood Center partners with local universities to advance research that supports the industry and hosts students from local colleges to support the next generation of blood drive staff. 

Connect with us 

The number one reason people don’t donate is because they have never been asked to give. Help us change that when you use #STLSavesLives when you give blood and share your reasons for supporting St. Louis patients and hospitals through blood donation.

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service region

We are proud to be the provider of blood products and services 25 hospitals in the St. Louis area and to more than 115 hospitals in Illinois, Iowa, Missouri and Wisconsin. As inventory allows, additional units are provided to hospitals across the country through a national resource sharing program.

st. louis region map

Anderson Hospital - Maryville, IL
Capital Region Medical Center - Jefferson City, MO
Gateway Regional Medical Center - Granite City, IL
HSHS St. Elizabeth’s Hospital - O’Fallon, IL
HSHS St. Joseph's Hospital - Breese, IL
HSHS St. Joseph's Hospital - Highland, IL
Mercy Hospital Jefferson - Crystal City, MO
Mercy Hospital Lincoln - Troy, MO
Mercy Hospital South - St. Louis, MO
Mercy Hospital St. Louis** - St. Louis, MO
Mercy Hospital Washington** - Washington, MO
OSF HealthCare Saint Anthony's Health Center - Alton, IL
SSM Health Cardinal Glennon Children’s Hospital - St. Louis, MO
SSM Health DePaul Hospital - St. Louis, MO
SSM Health Good Samaritan Hospital - Mt. Vernon, IL

SSM Health St. Clare Hospital - Fenton, MO
SSM Health St. Joseph Hospital - St. Charles, MO
SSM Health St. Joseph Hospital - Lake St. Louis, MO
SSM Health St. Louis University Hospital - St. Louis, MO
SSM Health St. Mary’s Hospital - Audrain-Mexico, MO
SSM Health St. Mary’s Hospital - St. Louis, MO
SSM Health St. Mary’s Hospital - Jefferson City, MO
SSM Health St. Mary's Hospital - Centralia, Illinois
St. Luke’s Des Peres Hospital - St. Louis, MO
Touchette Regional Hospital - Centreville, IL

**primary external supplemental provider to the blood program of Mercy Hospital St. Louis



Watch the stories of St. Louis blood recipients below!


Aniyah and Ashli

Aniyah and Ashli

Aniyah and Ashli share their story and the difference a diverse donor base can make for sickle cell patients.

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