UPDATE - Recent changes to donor eligibility criteria will permit donations by many donors previously deferred due to exposure Variant Creutzfeldt-Jacob Disease (vCJD or Mad Cow Disease). Questions about this change? Please fill out the deferral/eligibility inquiry form.

Click here for our response to the Coronavirus Pandemic (COVID-19) including information from the U.S. Department of Homeland Security on blood donation being permitted during Stay at Home directives. Click here for care provider and self-referrals for convalescent plasma donors for those that had a positive molecular test (also called PCR or polymerase chain reaction) and are fully recovered from COVID-19.  Email or call 833-610-1025 with questions.


Mississippi Valley Regional Blood Center will collect plasma donations from patients who have recovered from a COVID-19 infection to help newly diagnosed patients fight the disease. The treatment, known as convalescent plasma therapy, requires plasma provided by donors who have recently recovered from a COVID-19 infection. These donors will have antibodies to help fight COVID-19. The treatment has been used in recent years to treat victims of Ebola, SARS, and H1N1 influenza.

eligibility criteria

  • Must be at least 28 days from recovery of their COVID-19 infection
  • Must have had a positive molecular test (also called PCR or polymerase chain reaction), showing they had a COVID-19 infection. If you are unsure what kind of test you had, please ask your healthcare provider 
  • Meet all standard eligibility criteria for blood donation

Please note, potential convalescent plasma donors must meet above criteria to be eligible for this e-gift card.

All convalescent plasma donors will receive an $25 e-gift card!

antibody testing

The blood center does NOT do antibody testing on all donors. For Convalescent plasma donors, we only accept donors who HAVE HAD a positive molecular test for COVID-19 (SARS-Co-V-2 virus) with almost no exceptions.  There are several important reasons. 

  • Patients, who were sicker, who have had molecular confirmation, have higher levels of antibody needed in the Convalescent Plasma. Therefore, if CCP is proven effective, these donors are likely to provide a more effective product.  
  • Second, due to the large number of non-definitive antibody tests being used by various laboratories, most of which have not been well validated for their ability to identify good convalescent plasma donors, the Blood Center is unable to rely on these results provided by donors to determine high antibody levels. The FDA has determined that some of these tests provide misleading and inaccurate results. We are not using these screening test results as a primary way to identify Convalescent Plasma donors based on this. 
  • Additionally, screening large numbers of donors who have neither been ill nor had a positive molecular tests is an inefficient way to find donors and consumes testing resources that should be reserved for other uses.
  • Without good test results, individuals may be misled to inappropriate behavior and increased risk of disease spread. 

Donors without an initial positive molecular test but that have had antibody testing done, are encouraged to give a voluntary blood donation.  The products from traditional blood donations help save and enhance patient lives every day and are critical for patients in need.

If criteria changes, we will review and update our practices accordingly.

referral form

Click on the red button below for either self-referrals or care provider referrals.  After reviewing your submission, the Blood Center will follow up with potential donors to schedule a plasma donation at a MVRBC Donor Center. 

Self-Referral & Care Provider Referral Form


(833) 610-1025

Please note: US COVID Plasma EAP Hospital Blood Bank Transfusion Reaction Reporting Requirements The hospital blood bank is required to send a report to uscovidplasma@mayo.edu and  2-Quality@mvrbc.org for any transfusion-related reaction that occurs for patients enrolled in the EAP that receive convalescent plasma.

Social Media Toolkit

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All convalescent plasma donors will receive an $25 e-gift card!

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Quotes from Convalescent Plasma Donors

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Scroll down to watch the stories from convalescent plasma donors.


Dan - Convalescent Plasma Donor


Dan is changing the world.

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Deborah - Convalescent Plasma Donor


“Right now I feel like I have to help people. I feel like there's a reason I'm here now. So I'm going to help as much as I can.”

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Jose recovered from COVID-19 and now able to donate convalescent plasma donor which is used to help those still fighting COVID-19.


José is changing the world.

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Kim's Story


Kim is changing the world.

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Dr. Martin - Convalescent Plasma Donor


Dr. Martin is changing the world.

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Michael - Convalescent Plasma Donor


Michael is changing the world.

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Patrick's Story


Patrick is changing the world.

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